First controlled clinical trial in humans confirms graphene nanomaterials can be developed safely

British researchers have announced an important finding: The first strictly controlled exposure clinical trial in humans shows that inhaling certain types of graphene has no short-term adverse effects on lung or cardiovascular function. This means that graphene, a nanomaterial, can be developed safely further without posing significant risks to human health. The relevant paper was published in the journal Nature Nanomaterials on the 16th.

Screenshot of paper

Graphene was first isolated in 2004. It has the characteristics of ultra-thin, ultra-strong, ultra-flexible and is known as a "miracle" material. It may be used in areas such as electronic products, mobile phone screens, clothing, paint and water purification. In addition, scientists are actively exploring the role graphene can play in targeted treatments for cancer and other diseases, such as making it into implantable devices and sensors. However, before medical applications, all nanomaterials need to be tested for any potential adverse effects.

The human trials used ultrapure graphene oxide nanoflakes, a material that is miscible with water. Researchers from the Universities of Edinburgh and Manchester recruited 14 volunteers, who took part in the study under strictly controlled exposure and clinical monitoring conditions. Volunteers wore masks and breathed ultrapure graphene oxide for 2 hours while cycling in a specially designed mobile laboratory, and their lung function, blood pressure, coagulation and blood levels were measured before and every two hours after exposure. Inflammation levels. A few weeks later, the volunteers returned to the clinic for repeated controlled exposures to different qualities of graphene oxide or clean air for comparison.

The results showed that inhaling ultrapure graphene oxide had no adverse effects on lung function, blood pressure or most other biological parameters. The researchers noted there were slight indications that inhaling the substance might affect the way blood clots, but the effects were very small. However, further investigation is needed to determine the potential effects of higher doses and prolonged exposure to graphene.

Researchers say nanomaterials such as graphene are promising, but they must be manufactured in a safe way before they can be used more widely in life. A giant step forward in understanding how graphene affects the human body has been taken by exploring the safety of this unique material in human volunteers. The discovery could open the door to the development of new devices, treatments and monitoring techniques.