You can combine a precision instrumentation amplifier (IA)and an inexpensive CMOS op amp to get the best of twoworlds—the precision of a bipolar IA and 5V single-supplyoperation. Using the INA131 gives 50mV max voltageoffset, 0.25mV/°C max offset drift, and 110dB min commonmoderejection. How close the output swings to the powersupply rail depends on which “rail-to-rail” CMOS op ampyou use. With a TI TL2272 you can expect the output toswing within 100mV of the rails
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