Download>Category>>Transfer function analysis of dynamic cerebral blood flow autoregulation: a white paper from the International Cerebral Blood Flow Autoregulation Research Network

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Transfer function analysis of dynamic cerebral blood flow autoregulation: a white paper from the International Cerebral Blood Flow Autoregulation Research Network

2020-09-28
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Cerebral autoregulation (CA) is the intrinsic ability of the brain to maintain adequate cerebral perfusion in response to changes in blood pressure. In the past 30 years, researchers have proposed a number of methods for analyzing CA, but there is still no universally accepted gold standard, and the choice of which method to use to quantify CA remains subjective. Nevertheless, since the concept of CA represents the dynamic relationship between blood pressure (stimulus or input signal) and cerebral blood flow (response or output signal), the most common method for analyzing spontaneous fluctuations in blood pressure is transfer function analysis. Although theoretically feasible, the literature shows that transfer function analysis methods are subject to considerable subjectivity in practice, which limits comparisons between studies and hinders their clinical application. Therefore, this white paper aims to standardize the parameters and settings of transfer function analysis methods for studying dynamic CA and establish standards to facilitate their clinical application. The development of this recommendation began with (but is not limited to) the Cerebral Autoregulation Research Network (CARNet - www.car-net.org).

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